Self-assembling a molecular pegboard

J Am Chem Soc. 2005 Dec 21;127(50):17606-7. doi: 10.1021/ja0568446.

Abstract

This paper describes the design, construction, and application of a self-assembled, chemically addressable DNA nanogrid composed of DNA tiles of nanometer dimensions. This self-assembled structure permits precise placement of molecules at predetermined locations on a "molecular pegboard". We used the indexed DNA nanogrids to identify single molecules of DNA that hybridize at particular locations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA / chemical synthesis
  • DNA / chemistry*
  • Microarray Analysis
  • Microscopy, Atomic Force
  • Models, Molecular
  • Nanostructures / chemistry*
  • Nucleic Acid Conformation
  • Nucleic Acid Hybridization
  • Streptavidin / chemistry

Substances

  • DNA
  • Streptavidin