Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture

Biol Pharm Bull. 2006 Jan;29(1):174-6. doi: 10.1248/bpb.29.174.

Abstract

Geniposide from Gardenia jasminoides protected neuronal cells from damage in oxygen and glucose deprivation-exposed hippocampal slice culture. Geniposide showed a greater protective effect on the granule cell layer than on the pyramidal cell layer including CA 1 and CA 3. On the basis of the experimental results, geniposide may be a therapeutic agent for ischemia in patients.

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Gardenia / chemistry*
  • Glucose / deficiency*
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Hypoxia / pathology*
  • Iridoids / isolation & purification
  • Iridoids / pharmacology*
  • Neurons / drug effects*
  • Organ Culture Techniques
  • Pyramidal Cells / drug effects
  • Pyrans / isolation & purification
  • Pyrans / pharmacology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Iridoids
  • Pyrans
  • geniposide
  • Glucose