Abstract
Geniposide from Gardenia jasminoides protected neuronal cells from damage in oxygen and glucose deprivation-exposed hippocampal slice culture. Geniposide showed a greater protective effect on the granule cell layer than on the pyramidal cell layer including CA 1 and CA 3. On the basis of the experimental results, geniposide may be a therapeutic agent for ischemia in patients.
MeSH terms
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Animals
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Cell Death / drug effects
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Gardenia / chemistry*
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Glucose / deficiency*
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Hippocampus / cytology
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Hippocampus / drug effects*
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Hypoxia / pathology*
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Iridoids / isolation & purification
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Iridoids / pharmacology*
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Neurons / drug effects*
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Organ Culture Techniques
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Pyramidal Cells / drug effects
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Pyrans / isolation & purification
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Pyrans / pharmacology*
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Rats
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Rats, Sprague-Dawley
Substances
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Iridoids
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Pyrans
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geniposide
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Glucose