Abstract
Mice polytransgenic for chromosome 21 genes DSCR3, 5, 6, 9, and TTC3 within the Down Syndrome Critical Region-1 represent an animal model for Down Syndrome (DS). In a proteomic approach, we show a series of altered hippocampal protein levels that may be caused by overexpression of at least one of the five chromosome 21 genes and that fit fear-conditioned memory defects and were observed to be dysregulated in human fetal DS.
MeSH terms
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Animals
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Chromosomes, Human, Pair 21 / genetics*
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Down Syndrome / genetics
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Down Syndrome / metabolism*
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Gene Expression Regulation
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Hippocampus / chemistry
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Hippocampus / metabolism*
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Humans
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Mice
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Mice, Transgenic
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Protein Biosynthesis / genetics
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Proteins / analysis
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Proteins / genetics
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Proteins / metabolism
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Proteome / analysis
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Proteome / genetics
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Proteome / metabolism*
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Proteomics
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RNA, Messenger / analysis
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RNA, Messenger / metabolism
Substances
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Proteins
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Proteome
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RNA, Messenger