Abstract
Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3beta-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.
MeSH terms
-
Breast Neoplasms / genetics
-
Breast Neoplasms / metabolism*
-
Breast Neoplasms / pathology
-
Carcinoma, Ductal, Breast / metabolism*
-
Carcinoma, Ductal, Breast / pathology
-
Carcinoma, Intraductal, Noninfiltrating / metabolism
-
Carcinoma, Intraductal, Noninfiltrating / pathology
-
DNA-Binding Proteins / metabolism*
-
Female
-
Gene Expression Profiling
-
Humans
-
Immunoenzyme Techniques
-
Middle Aged
-
Neoplasm Invasiveness
-
Neoplasm Proteins / genetics
-
Neoplasm Proteins / metabolism
-
Oligonucleotide Array Sequence Analysis
-
Phosphoproteins / genetics
-
Phosphoproteins / metabolism*
-
Receptor, ErbB-2 / metabolism
-
Receptors, Cytoplasmic and Nuclear / metabolism*
-
Transcription Factors / metabolism*
Substances
-
DNA-Binding Proteins
-
NR5A2 protein, human
-
Neoplasm Proteins
-
Phosphoproteins
-
Receptors, Cytoplasmic and Nuclear
-
Transcription Factors
-
steroidogenic acute regulatory protein
-
Receptor, ErbB-2