Abstract
A novel series of pyridone inhibitors has been identified through pharmacophore analysis, as potent antagonists of VLA-4.
MeSH terms
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Binding Sites
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Drug Design
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Integrin alpha4beta1 / antagonists & inhibitors*
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Pyridones / chemical synthesis*
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Pyridones / pharmacology*
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Structure-Activity Relationship
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Vascular Cell Adhesion Molecule-1 / metabolism
Substances
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Integrin alpha4beta1
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Pyridones
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Vascular Cell Adhesion Molecule-1