Abstract
A new antitumor substance, BE-13793C, which has topoisomerase inhibitory activity was isolated from the culture broth of a strain of actinomycetes. The producing strain, BA13793, isolated from a soil sample collected in Seto, Aichi Prefecture, Japan, has a resemblance to Streptoverticillium mobaraense. The active principle was extracted from the mycelium of strain BA13793 with methanol and purified by Sephadex LH-20 column chromatography. BE-13793C showed strong inhibitory activity against topoisomerases I and II and inhibited the growth of doxorubicin-resistant or vincristine-resistant P388 murine leukemia cell lines, as well as their parent P388 cell line.
MeSH terms
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Animals
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Antibiotics, Antineoplastic* / chemistry
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Antibiotics, Antineoplastic* / isolation & purification
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Antibiotics, Antineoplastic* / therapeutic use
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Carbazoles*
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Carcinoma, Ehrlich Tumor / drug therapy
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Chemical Phenomena
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Chemistry, Physical
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Fermentation
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Indoles / chemistry
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Indoles / isolation & purification*
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Indoles / therapeutic use
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Leukemia L1210 / enzymology
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Leukemia P388 / drug therapy
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Neoplasm Transplantation
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Pyrroles / chemistry
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Pyrroles / isolation & purification*
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Pyrroles / therapeutic use
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Streptomycetaceae / classification
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Streptomycetaceae / metabolism*
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
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Tumor Cells, Cultured
Substances
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Antibiotics, Antineoplastic
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Carbazoles
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Indoles
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Pyrroles
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
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BE 13793C