Three-dimensional chiral imaging by sum-frequency generation

Na Ji; Kai Zhang; Haw Yang; Yuen-Ron Shen

doi:10.1021/ja057775y

Three-dimensional chiral imaging by sum-frequency generation

J Am Chem Soc. 2006 Mar 22;128(11):3482-3. doi: 10.1021/ja057775y.

Authors

Na Ji¹, Kai Zhang, Haw Yang, Yuen-Ron Shen

Affiliation

¹ Department of Physics, University of California at Berkeley, Berkeley, California 94720, USA.

PMID: 16536497
DOI: 10.1021/ja057775y

Abstract

A sum-frequency generation (SFG) microscope that is sensitive toward molecular chirality was demonstrated for the first time. Optically active images of chiral 1,1'-bi-2-naphthol solutions were obtained with submicron spatial resolution. Three-dimensional sectioning capability of our microscope was also demonstrated. This optically active SFG microscopy can potentially become a powerful imaging technique for biological samples.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Image Processing, Computer-Assisted / methods*
Microscopy, Fluorescence / methods
Naphthols / chemistry*
Stereoisomerism

Substances

BINOL, naphthol
Naphthols