Abstract
As one of two Drosophila Hox clusters, the bithorax complex (BX-C) is responsible for determining the posterior thorax and each abdominal segment of the fly. Through the dissection of its large cis-regulatory region, biologists have obtained a wealth of knowledge that has informed our understanding of gene expression, chromatin dynamics and gene evolution. This primer attempts to distill and explain our current knowledge about this classic, complex locus.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Drosophila Proteins / biosynthesis
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Drosophila Proteins / genetics*
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Drosophila Proteins / physiology
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Drosophila melanogaster / chemistry
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Drosophila melanogaster / genetics*
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Drosophila melanogaster / physiology
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Genes, Homeobox*
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Homeodomain Proteins / biosynthesis
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / physiology
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Multigene Family*
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Nuclear Proteins / biosynthesis
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Nuclear Proteins / genetics*
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Nuclear Proteins / physiology
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Transcription Factors / biosynthesis
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Transcription Factors / genetics*
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Transcription Factors / physiology
Substances
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Abd-B proteins, Drosophila
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Drosophila Proteins
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Homeodomain Proteins
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Nuclear Proteins
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Transcription Factors
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Ubx protein, Drosophila
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abd-A protein, Drosophila