Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate

Yuqiang Wang; Lianfa Li; Wei Jiang; Zhaoqi Yang; Zaijun Zhang

doi:10.1016/j.bmcl.2006.02.066

Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2974-7. doi: 10.1016/j.bmcl.2006.02.066. Epub 2006 Mar 24.

Authors

Yuqiang Wang¹, Lianfa Li, Wei Jiang, Zhaoqi Yang, Zaijun Zhang

Affiliation

¹ Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China. yuqiangwang2001@yahoo.com

PMID: 16563756
DOI: 10.1016/j.bmcl.2006.02.066

Abstract

A conjugate of DHA and doxorubicin (DHA-Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA-Dox showed a greatly improved antitumor efficacy compared to free doxorubicin.

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use*
Antineoplastic Agents / toxicity
Body Weight / drug effects
Cell Line, Tumor
Docosahexaenoic Acids / chemistry*
Doxorubicin / chemistry*
Mice
Molecular Structure
Neoplasm Transplantation
Neoplasms / drug therapy
Neoplasms / pathology
Paclitaxel / chemistry

Substances

Antineoplastic Agents
Docosahexaenoic Acids
Doxorubicin
Paclitaxel