Abstract
Platelet function and fatty acid composition were investigated in 30 healthy male subjects who ate a controlled-saturated-fatty-acid (baseline) diet for 3 wk and then consumed either safflower oil or canola oil as a major fat source for 8 wk. Fatty acid composition of platelet phospholipids reflected changes in dietary fatty acid composition. Compared with baseline a 35% decrease (P less than 0.05) in arachidonic acid was observed in platelet phospholipids of the canola-oil diet group while long chain n-3 fatty acids rose 7-26% (P greater than 0.05). Compared with baseline both unsaturated-fatty-acid diets reduced platelet aggregation at 3 wk of oil-based diet feeding (P less than 0.01) whereas only canola oil influenced platelet function (lowered ATP secretion) at 8 wk (P less than 0.01). No significant difference was observed in thromboxane B2 concentrations between oil-treatment groups at 8 wk. Both oil-based diets had short-term beneficial effects on platelet function but the effect of canola oil persisted longer.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenosine Triphosphate / blood
-
Adult
-
Arachidonic Acid
-
Arachidonic Acids / blood
-
Blood Platelets / physiology*
-
Collagen / pharmacology
-
Dietary Fats / administration & dosage
-
Dietary Fats / pharmacology*
-
Dietary Fats, Unsaturated / administration & dosage
-
Dietary Fats, Unsaturated / pharmacology*
-
Fatty Acids / administration & dosage
-
Fatty Acids / blood
-
Fatty Acids / pharmacology*
-
Fatty Acids, Monounsaturated / administration & dosage
-
Fatty Acids, Monounsaturated / pharmacology
-
Humans
-
Linolenic Acids / blood
-
Male
-
Middle Aged
-
Oleic Acid
-
Oleic Acids / blood
-
Phospholipids / blood*
-
Platelet Aggregation / drug effects
-
Platelet Aggregation Inhibitors / pharmacology
-
Rapeseed Oil
-
Safflower Oil / administration & dosage
-
Safflower Oil / pharmacology
-
Thromboxane B2 / biosynthesis*
-
alpha-Linolenic Acid
Substances
-
Arachidonic Acids
-
Dietary Fats
-
Dietary Fats, Unsaturated
-
Fatty Acids
-
Fatty Acids, Monounsaturated
-
Linolenic Acids
-
Oleic Acids
-
Phospholipids
-
Platelet Aggregation Inhibitors
-
Rapeseed Oil
-
alpha-Linolenic Acid
-
Arachidonic Acid
-
Oleic Acid
-
Thromboxane B2
-
Safflower Oil
-
Adenosine Triphosphate
-
Collagen