The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer

J Mol Histol. 2006 Sep;37(5-7):219-23. doi: 10.1007/s10735-006-9042-9. Epub 2006 Jul 20.

Abstract

The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to tumorigenesis in multiple organs. In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / metabolism
  • DNA Repair*
  • DNA-Binding Proteins / metabolism
  • DNA-Binding Proteins / physiology*
  • Enhancer of Zeste Homolog 2 Protein
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Polycomb Repressive Complex 2
  • Polycomb-Group Proteins
  • Recombination, Genetic
  • Repressor Proteins / physiology*
  • Transcription Factors / metabolism
  • Transcription Factors / physiology*
  • Transcription, Genetic

Substances

  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • Polycomb-Group Proteins
  • Repressor Proteins
  • Transcription Factors
  • EZH2 protein, human
  • Enhancer of Zeste Homolog 2 Protein
  • Polycomb Repressive Complex 2