Abstract
Yersinia pseudotuberculosis mutants deficient for the adhesins invasin and/or YadA were injected intravenously into BALB/c mice. Invasin expression inhibited colonization of the liver and spleen. YadA decreased liver colonization but promoted growth within the lung. The persistence of leukocytes within liver microabscesses correlated with enhanced colonization and lack of adhesin expression.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adhesins, Bacterial / biosynthesis
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Adhesins, Bacterial / genetics
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Adhesins, Bacterial / physiology*
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Animals
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Disease Models, Animal
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Macrophages / immunology
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Macrophages / microbiology
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Male
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Mice
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Mice, Inbred BALB C
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Mutation
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Neutrophils / immunology
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Neutrophils / microbiology
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Organ Specificity / immunology*
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T-Lymphocytes / immunology
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T-Lymphocytes / microbiology
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Yersinia pseudotuberculosis / growth & development*
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Yersinia pseudotuberculosis / immunology*
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Yersinia pseudotuberculosis Infections / immunology*
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Yersinia pseudotuberculosis Infections / microbiology
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Yersinia pseudotuberculosis Infections / pathology
Substances
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Adhesins, Bacterial
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YadA protein, Yersinia
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invasin, Yersinia