Health-related quality-of-life scores depend on patients' judgments about their condition and its effect on them. Asthma is a long-term disease, and it is possible that patients may learn to accept some of its effects. We tested the hypothesis that patients come to accept some asthma effects and then discount them as being important when rating their health. We asked patients which of the asthma effects listed in the St. George's Respiratory Questionnaire were acceptable to them. This enabled us to calculate a score for effects of asthma that patients experienced, yet were acceptable to them. The comparative validity of the Current, Acceptable and Unacceptable St George's Respiratory Questionnaire scores was examined by testing their correlations with a variety of asthma-related variables. Eighty patients participated, mean age 50 years, mean forced expiratory volume in 1 second (FEV1) 73 (SD 24)% predicted. Acceptability of St George's Respiratory Questionnaire items was related to the previously identified severity weights (rho = -0.65, p < 0.0001), but some severe effects were acceptable to some patients. Patients who accepted higher levels of health impairment were older with more severe disease. Unacceptable health was less well correlated with asthma-related variables than was current health. We conclude that patients accept some asthma effects but do not appear to discount them when using a detailed health status questionnaire.