Decreased number of peripheral blood CD4 + CD29+ lymphocytes and increased in vitro spontaneous production of anti-DNA antibodies in patients with active systemic lupus erythematosus

J Rheumatol. 1990 Aug;17(8):1048-53.

Abstract

Flow cytometric 2-color analysis of peripheral blood lymphocytes from patients with systemic lupus erythematosus (SLE) showed a reduction of relative and absolute number of CD4+ CD29+ cells compared to matched healthy individuals. This abnormality was more marked in patients with active/very active disease. Absolute number of CD4+ CD29+ cells was negatively correlated with spontaneous anti-DNA Ig production that we demonstrated to be a laboratory index strongly correlated with a clinical disease activity score. A decrease of the percentage of CD8+ CD29+ lymphocytes in patients with active disease was also observed.

MeSH terms

  • Adult
  • Antigens, CD / immunology
  • Antigens, Differentiation / immunology
  • Autoantibodies / biosynthesis*
  • CD4-Positive T-Lymphocytes / immunology*
  • DNA / immunology*
  • Female
  • Flow Cytometry
  • Humans
  • Integrin beta1
  • Leukocyte Count
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • T-Lymphocyte Subsets / immunology*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Autoantibodies
  • Integrin beta1
  • DNA