A comparison of the relative rates of hemolysis induced by various fibrogenic and non-fibrogenic particles with washed rat erythrocytes in vitro

Am Ind Hyg Assoc J. 1975 Oct;36(10):734-40. doi: 10.1080/0002889758507332.

Abstract

Correlations between in vitro hemolytic activity and the in vivo fibrogenic activity of a number of particulate materials are demonstrated. Fibrogenic particles are capable of inducing hemolysis, while non-fibrogenic particles are not. It is suggested that particulates inducing a rate of hemolysis greater than 1 X 10(-4) min-1 may be fibrogenic.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Asbestos / toxicity
  • Biphenyl Compounds / toxicity
  • Calcium / toxicity
  • Ceramics
  • Erythrocytes / drug effects
  • Hemolysis / drug effects*
  • Hydrocarbons, Brominated / toxicity
  • Kaolin / toxicity
  • Magnesium / toxicity
  • Particle Size
  • Phosphates / toxicity
  • Pulmonary Fibrosis / chemically induced*
  • Rats
  • Silicic Acid / toxicity
  • Silicon Dioxide / toxicity
  • Talc / toxicity
  • Titanium / toxicity

Substances

  • Biphenyl Compounds
  • Hydrocarbons, Brominated
  • Phosphates
  • Asbestos
  • Silicic Acid
  • Talc
  • Kaolin
  • Silicon Dioxide
  • Titanium
  • Magnesium
  • Calcium