Is the beneficial effect of sulfasalazine due to inhibition of synovial neovascularization?

R Madhok; E Wijelath; J Smith; J Watson; R D Sturrock; H A Capell

Is the beneficial effect of sulfasalazine due to inhibition of synovial neovascularization?

J Rheumatol. 1991 Feb;18(2):199-202.

Authors

R Madhok¹, E Wijelath, J Smith, J Watson, R D Sturrock, H A Capell

Affiliation

¹ Centre for Rheumatic Diseases, University Department of Medicine, Glasgow Royal Infirmary, Scotland, UK.

PMID: 1708829

Abstract

Angiogenesis is fundamental to support the continued synovial proliferation observed in rheumatoid arthritis. We investigated the effects of sulfasalazine and its metabolites on endothelial cell proliferation, a prerequisite to angiogenesis. At concentrations achieved in vivo sulfapyridine inhibited basal and endothelial cell growth factor stimulated endothelial cell proliferation. Sulfasalazine and 5 amino salicylic acid had no effect.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminosalicylic Acids / pharmacology
Arthritis, Rheumatoid / drug therapy
Arthritis, Rheumatoid / pathology
Arthritis, Rheumatoid / physiopathology*
Cell Division / drug effects
Endothelium, Vascular / cytology
Endothelium, Vascular / drug effects
Humans
Mesalamine
Middle Aged
Monocytes / drug effects
Neovascularization, Pathologic / pathology
Sulfasalazine / pharmacology*
Sulfasalazine / therapeutic use
Synovial Membrane / blood supply*
Synovial Membrane / cytology
Synovial Membrane / drug effects

Substances

Aminosalicylic Acids
Sulfasalazine
Mesalamine