1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors

Bioorg Med Chem Lett. 2007 Feb 15;17(4):1091-7. doi: 10.1016/j.bmcl.2006.11.016. Epub 2006 Nov 10.

Abstract

A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Area Under Curve
  • Binding Sites
  • Biological Availability
  • Crystallography, X-Ray
  • Databases, Protein
  • Half-Life
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology*
  • Indicators and Reagents
  • Mice
  • Models, Molecular
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Pyrazines / chemical synthesis*
  • Pyrazines / pharmacology*
  • Receptor, IGF Type 1 / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Imidazoles
  • Indicators and Reagents
  • Pyrazines
  • Adenosine Triphosphate
  • Protein-Tyrosine Kinases
  • Receptor, IGF Type 1