HuR: post-transcriptional paths to malignancy

RNA Biol. 2005 Jan;2(1):11-3. doi: 10.4161/rna.2.1.1552. Epub 2005 Jan 19.

Abstract

The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While no HuR mutations have been found in cancer, a link between HuR and malignant transformation has been suggested in cancers of the breast, colon, lung and ovary. We describe a paradigm consistent with a central role of HuR in oncogenesis.

MeSH terms

  • Animals
  • Antigens, Surface / metabolism*
  • Carcinoma, Non-Small-Cell Lung / metabolism
  • Cell Line, Tumor
  • Cell Nucleus / metabolism
  • Cell Transformation, Neoplastic*
  • Chromosomes, Human, Pair 19
  • Colonic Neoplasms / metabolism
  • Cytoplasm / metabolism
  • ELAV Proteins
  • ELAV-Like Protein 1
  • Humans
  • Mice
  • Mice, Nude
  • Protein Biosynthesis
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / metabolism*

Substances

  • Antigens, Surface
  • ELAV Proteins
  • ELAV-Like Protein 1
  • ELAVL1 protein, human
  • RNA, Messenger
  • RNA-Binding Proteins