Abstract
Obesity is often associated with diabetes and insulin resistance. This review summarizes evidence obtained in our lab on the role of the serine phosphorylation of the insulin receptor substrate 1 in the down regulation of insulin signalling. The role of the ERK1 isoform in the development of adipose tissue and insulin sensitivity is also presented.
MeSH terms
-
Adipose Tissue / physiology
-
Adipose Tissue / physiopathology
-
Diabetes Mellitus / physiopathology*
-
Humans
-
Insulin / physiology*
-
Insulin Receptor Substrate Proteins
-
Insulin Resistance / physiology*
-
Mitogen-Activated Protein Kinase 3 / metabolism
-
Obesity / physiopathology*
-
Phosphoproteins / physiology
-
Signal Transduction / physiology*
Substances
-
IRS1 protein, human
-
Insulin
-
Insulin Receptor Substrate Proteins
-
Phosphoproteins
-
Mitogen-Activated Protein Kinase 3