Abstract
Bioassay guided purification of the ethanolic extract of the bark of New Caledonian Pittosporum pancheri Brongn. and Gris (Pittosporaceae) led to the isolation and characterization of two new farnesyl monoglycosides, pancherins A and B. The structure of these compounds were determined on the basis of spectroscopic studies. The new compounds displayed a significant activity in the in vitro cytotoxic assay against KB cancer cell line, and pancherin A inhibits weakly farnesyl protein transferase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology
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Chromatography, High Pressure Liquid
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / toxicity
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Humans
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KB Cells / drug effects
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Magnetic Resonance Spectroscopy
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Stems / chemistry
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Rosales / chemistry*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / toxicity
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Substances
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Antineoplastic Agents
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Glycosides
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Plant Extracts
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Sesquiterpenes