Abstract
The influence of liposome-entrapped catalase and/or superoxide dismutase on phospholipids of the lung surfactant in bleomycin-treated rats was investigated. Changes in phospholipid composition of lung surfactant were much pronounced in animals supplemented with antioxidant enzymes-loaded liposomes. It is suggested that liposomes are good carriers for drugs in bleomycin-induced lung injury treatment.
MeSH terms
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Animals
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Bleomycin
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Bronchoalveolar Lavage Fluid / chemistry
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Catalase / pharmacology*
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Chromatography, Thin Layer
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Drug Carriers
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Liposomes
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Male
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Phospholipids / metabolism*
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Pulmonary Fibrosis / chemically induced
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Pulmonary Fibrosis / metabolism
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Pulmonary Fibrosis / prevention & control*
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Pulmonary Surfactants / metabolism*
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Rats
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Rats, Inbred Strains
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Superoxide Dismutase / pharmacology*
Substances
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Drug Carriers
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Liposomes
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Phospholipids
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Pulmonary Surfactants
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Bleomycin
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Catalase
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Superoxide Dismutase