Simulation of pulmonary pathophysiology during spontaneous breathing

Y C Zhao; S E Rees; S Andreassen; S Kjaergaard

doi:10.1109/IEMBS.2005.1615892

Simulation of pulmonary pathophysiology during spontaneous breathing

Conf Proc IEEE Eng Med Biol Soc. 2005:2005:6128-31. doi: 10.1109/IEMBS.2005.1615892.

Authors

Y C Zhao¹, S E Rees, S Andreassen, S Kjaergaard

Affiliation

¹ Center for Model-based Medical Decision Support, Alborg University, Denmark.

PMID: 17281662
DOI: 10.1109/IEMBS.2005.1615892

Abstract

This paper presents a functional model of lung mechanics including a non-linear alveolar pressure volume curve and representation of the work of respiratory muscles during breathing. The model is used to simulate the response to forced inspiration and expiration, and these simulations compared to the standard results of lung function tests routinely performed in departments of lung medicine. The model can simulate the characteristics of inspiratory and expiratory flow profiles seen in normal subjects, and in patients with obstructive or restrictive diseases.