Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population

Neuroreport. 2007 Feb 12;18(3):273-5. doi: 10.1097/WNR.0b013e32801254b6.

Abstract

To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan and Singapore. Genotyping was conducted in 448 Parkinson disease patients and 457 healthy controls. The frequency of A allele in Parkinson disease was significantly higher than in the control (P=1.24x10(-4), odds ratio 2.63, 95% confidence interval 1.56-4.35). Our results suggest that the G2385R variant is a risk factor for sporadic Parkinson disease in the Asian population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asia / ethnology
  • Brain / enzymology
  • Brain / physiopathology
  • Brain Chemistry / genetics*
  • Cohort Studies
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genetic Markers
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • Humans
  • Japan / ethnology
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Male
  • Middle Aged
  • Mutation / genetics
  • Parkinson Disease / enzymology*
  • Parkinson Disease / ethnology
  • Parkinson Disease / genetics*
  • Protein Serine-Threonine Kinases / genetics*

Substances

  • Genetic Markers
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein Serine-Threonine Kinases