Abstract
Bromo- and iodoalkenes undergo trifluoromethylation efficiently in DMA with "CF3Cu" generated from (CF3)2Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retention.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry*
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Bromides / chemistry*
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Fluorine / chemistry*
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Iodides / chemistry*
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Methylation
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Molecular Structure
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Organometallic Compounds / chemistry*
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Uracil / chemistry*
Substances
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Alkenes
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Bromides
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Iodides
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Organometallic Compounds
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trifluoromethylcopper
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Fluorine
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Uracil