We present a case of a 40-year-old woman with a history of a wide local excision for a melanoma and subsequent postoperative soft tissue loss who was successfully treated with injectable poly-L-lactic acid (Sculptra). After only one treatment with the filler agent, the treated area showed significant volume enhancement and improved cosmesis 10 months postinjection. We propose a possible role for injectable poly-L-lactic acid in improving the appearance of postoperative volume loss.