Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle

Alice Nemajerova; Ute M Moll; Oleksi Petrenko; Günter Fingerle-Rowson

doi:10.4161/cc.6.9.4163

Macrophage migration inhibitory factor coordinates DNA damage response with the proteasomal control of the cell cycle

Cell Cycle. 2007 May 2;6(9):1030-4. doi: 10.4161/cc.6.9.4163. Epub 2007 May 20.

Authors

Alice Nemajerova¹, Ute M Moll, Oleksi Petrenko, Günter Fingerle-Rowson

Affiliation

¹ Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York, USA.

PMID: 17426455
DOI: 10.4161/cc.6.9.4163

Abstract

Proper repair of DNA damage is critical for protecting genomic stability, cellular viability and suppression of tumorigenesis. Both p53-dependent and p53-independent pathways have evolved to coordinate the cellular response following DNA damage. In this review, we highlight the importance of the ubiquitously expressed protein macrophage migration inhibitory factor (MIF) for an appropriate response to DNA damage. We discuss the mechanisms by which MIF affects the activity of the ubiquitin-proteasome system, and how this impacts on the integrity of the genome and on cancer.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Cycle* / genetics
Cell Cycle* / physiology
DNA Damage / physiology*
G2 Phase
Genes, cdc
Humans
In Situ Hybridization, Fluorescence
Macrophage Migration-Inhibitory Factors / genetics
Macrophage Migration-Inhibitory Factors / physiology*
Models, Biological
Neoplasms / genetics
Neoplasms / metabolism
Proteasome Endopeptidase Complex / metabolism*
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism
Ubiquitin / metabolism

Substances

Macrophage Migration-Inhibitory Factors
Tumor Suppressor Protein p53
Ubiquitin
Proteasome Endopeptidase Complex