Sulfonylurea-responsive diabetes in childhood

J Pediatr. 2007 May;150(5):553-5. doi: 10.1016/j.jpeds.2007.03.004.

Abstract

We describe a family in which 3/6 siblings had transient, relapsing neonatal diabetes. The father and another sibling had diabetes diagnosed at 20 and 9 years old, respectively. All affected individuals carried the same KCNJ11 gene mutation. In all, sulfonylurea treatment permitted cessation of insulin treatment, with improved glycemic control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / genetics
  • Female
  • Glyburide / therapeutic use*
  • Humans
  • Hypoglycemic Agents / therapeutic use*
  • Infant, Newborn
  • Male
  • Mutation
  • Pedigree
  • Potassium Channels, Inwardly Rectifying / genetics
  • Sulfonylurea Compounds / therapeutic use

Substances

  • Hypoglycemic Agents
  • Kir6.2 channel
  • Potassium Channels, Inwardly Rectifying
  • Sulfonylurea Compounds
  • Glyburide