Abstract
We describe a family in which 3/6 siblings had transient, relapsing neonatal diabetes. The father and another sibling had diabetes diagnosed at 20 and 9 years old, respectively. All affected individuals carried the same KCNJ11 gene mutation. In all, sulfonylurea treatment permitted cessation of insulin treatment, with improved glycemic control.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Child
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Diabetes Mellitus / drug therapy*
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Diabetes Mellitus / genetics
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Female
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Glyburide / therapeutic use*
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Humans
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Hypoglycemic Agents / therapeutic use*
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Infant, Newborn
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Male
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Mutation
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Pedigree
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Potassium Channels, Inwardly Rectifying / genetics
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Sulfonylurea Compounds / therapeutic use
Substances
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Hypoglycemic Agents
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Kir6.2 channel
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Potassium Channels, Inwardly Rectifying
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Sulfonylurea Compounds
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Glyburide