Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats

FEBS Lett. 2007 May 15;581(10):2027-35. doi: 10.1016/j.febslet.2007.04.036. Epub 2007 Apr 24.

Abstract

Cisplatin is a widely used antineoplastic drug. Major drawback of cisplatin therapy is its nephrotoxicity. The objective of this study was to check the effect of tannic acid on cisplatin induced nephrotoxicity. Post-treatment of tannic acid prevents cisplatin (5mg/kg) induced nephrotoxicity and decreases poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 and hypoacetylation of histone H4. In contrast, co-treatment of tannic acid potentiates the nephrotoxicity. Comparative nephrotoxicity studies show that co-treatment of tannic acid with reduced dose of cisplatin (1.5mg/kg) developed almost similar nephrotoxicity. MALDI protein profiling of plasma samples provides indirect evidence that tannic acid co-treatment increases bioavailability of cisplatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation / drug effects
  • Animals
  • Antineoplastic Agents / toxicity*
  • Blood Proteins / chemistry
  • Blood Urea Nitrogen
  • Body Weight / drug effects
  • Cisplatin / toxicity*
  • Creatinine / blood
  • Dose-Response Relationship, Drug
  • Histones / metabolism
  • Kidney / drug effects
  • Kidney / enzymology
  • Kidney / pathology
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / pathology*
  • Male
  • Phosphorylation / drug effects
  • Poly(ADP-ribose) Polymerases / metabolism
  • Protein Processing, Post-Translational / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Serum Albumin
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Tannins / pharmacology*
  • p38 Mitogen-Activated Protein Kinases / metabolism

Substances

  • Antineoplastic Agents
  • Blood Proteins
  • Histones
  • Serum Albumin
  • Tannins
  • Creatinine
  • Poly(ADP-ribose) Polymerases
  • p38 Mitogen-Activated Protein Kinases
  • Cisplatin