Nonsporulating clinical isolate identified as Petromyces alliaceus (anamorph Aspergillus alliaceus) by morphological and sequence-based methods

J Clin Microbiol. 2007 Aug;45(8):2701-3. doi: 10.1128/JCM.00642-07. Epub 2007 May 30.

Abstract

Concerted morphological and sequencing-based strategies revealed the identity of a nonsporulating clinical isolate as Petromyces alliaceus (anamorph Aspergillus alliaceus). This rare Aspergillus sp. was recovered as the etiological agent of invasive pulmonary aspergillosis and had reduced in vitro susceptibilities to amphotericin B and caspofungin, which correlated with clinical failure of therapy.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology
  • Aspergillosis, Allergic Bronchopulmonary / drug therapy
  • Aspergillosis, Allergic Bronchopulmonary / microbiology*
  • Aspergillus / cytology*
  • Aspergillus / drug effects
  • Aspergillus / genetics*
  • Aspergillus / isolation & purification
  • Caspofungin
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • DNA, Ribosomal Spacer / chemistry
  • DNA, Ribosomal Spacer / genetics
  • Echinocandins
  • Female
  • Humans
  • Lipopeptides
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Sequence Data
  • Peptides, Cyclic / pharmacology
  • RNA, Ribosomal, 28S / genetics
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid

Substances

  • Antifungal Agents
  • DNA, Fungal
  • DNA, Ribosomal
  • DNA, Ribosomal Spacer
  • Echinocandins
  • Lipopeptides
  • Peptides, Cyclic
  • RNA, Ribosomal, 28S
  • Amphotericin B
  • Caspofungin

Associated data

  • GENBANK/EF447422
  • GENBANK/EF447423