Abstract
The coding polymorphism (rs1130866) within the surfactant protein B gene is known to associate with certain respiratory abnormalities. We investigated, using spirometry and fluorescence-based PCR, whether this variant influenced pulmonary function in healthy, nonsmoking men. We found no association of pulmonary function with genotype at the rs1130866 locus.
MeSH terms
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Adult
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Cohort Studies
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Exons
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Forced Expiratory Volume / genetics
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Gene Frequency
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Genetic Predisposition to Disease
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Humans
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Male
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Polymorphism, Single Nucleotide / physiology*
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Pulmonary Surfactant-Associated Protein B* / genetics
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Pulmonary Surfactant-Associated Protein B* / physiology
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Pulmonary Surfactants / metabolism
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Pulmonary Ventilation / genetics*
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Vital Capacity / genetics
Substances
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Pulmonary Surfactant-Associated Protein B
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Pulmonary Surfactants