Abstract
Serotonin, acting through a cAMP-signaling pathway, delayed habituation to criterion of the leech's swim response to touch. This delay was reversed by crushing the connective between serotonin-exposed and serotonin-naive ganglia, and correlated with an increase in spontaneous impulse activity in this connective. We suggest that increased activity in intersegmental interneurons may play a role in maintaining swim responsiveness when concentrations of serotonin are elevated.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Action Potentials / drug effects
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Analysis of Variance
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Animals
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Behavior, Animal / drug effects
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Behavior, Animal / physiology
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Cyclic AMP / analogs & derivatives
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Cyclic AMP / pharmacology
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Drug Interactions / radiation effects
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Ganglia, Invertebrate / cytology
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Habituation, Psychophysiologic / drug effects*
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Imines / pharmacology
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In Vitro Techniques
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Interneurons / drug effects
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Leeches / physiology*
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Locomotion / drug effects*
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Protein Kinase Inhibitors / pharmacology
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Serotonin / pharmacology*
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Swimming
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Thionucleotides / pharmacology
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Touch*
Substances
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Imines
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Protein Kinase Inhibitors
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Thionucleotides
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adenosine-3',5'-cyclic phosphorothioate
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Serotonin
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RMI 12330A
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Cyclic AMP