DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

Jennifer Lee; Pengbo Zhou

doi:10.1016/j.molcel.2007.06.001

DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

Mol Cell. 2007 Jun 22;26(6):775-80. doi: 10.1016/j.molcel.2007.06.001.

Authors

Jennifer Lee¹, Pengbo Zhou

Affiliation

¹ Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.

PMID: 17588513
DOI: 10.1016/j.molcel.2007.06.001

Abstract

The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. Recent work identified a family of DDB1 and CUL4-associated factors (DCAFs) as substrate receptors, implicating a broad spectrum of cellular processes regulated by CUL4-DDB1.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Proliferation
Cell Survival / physiology
Cullin Proteins / genetics
Cullin Proteins / metabolism*
DNA Repair / physiology
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Genomic Instability / physiology
Humans
Protein Processing, Post-Translational / physiology*
Ubiquitin / genetics
Ubiquitin / metabolism*

Substances

Cullin Proteins
DDB1 protein, human
DNA-Binding Proteins
Ddb1 protein, mouse
Ddb1 protein, rat
Ubiquitin