Abstract
A triterpene saponoside (LTS-4) isolated from the underground parts of Lysimachia thyrsiflora L. was defined as 3-O-{beta-D-xylopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-alpha-L-arabinopyranosyl}-cyclamiretin A. Structure assignment was performed on the basis of spectroscopic data including homo- and heteronuclear 1D and 2D NMR (COSY, TOCSY, NOESY, HETCOR, HMBC and DEPT) and FAB-MS studies. The compound was tested in vitro for antimicrobial and cytotoxic activity.
MeSH terms
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Animals
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mice
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Roots
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Primulaceae / chemistry*
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Saponins / isolation & purification
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Saponins / pharmacology*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
Substances
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3-O-(beta-D-xylopyranosyl-(1-2)-beta-D-glucopyranosyl-(1-4)-(beta-D-glucopyranosyl-(1-2))-alpha-L-arabinopyranosyl)cyclamiretin A
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Anti-Bacterial Agents
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Antifungal Agents
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Antineoplastic Agents
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Plant Extracts
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Saponins
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Triterpenes
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Oleanolic Acid