Activity-dependent signaling pathways controlling muscle diversity and plasticity

Physiology (Bethesda). 2007 Aug:22:269-78. doi: 10.1152/physiol.00009.2007.

Abstract

A variety of fiber types with different contractile and metabolic properties is present in mammalian skeletal muscle. The fiber-type profile is controlled by nerve activity via specific signaling pathways, whose identification may provide potential therapeutic targets for the prevention and treatment of metabolic and neuromuscular diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcineurin / physiology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Humans
  • Mice
  • Muscle Contraction / physiology
  • Muscle, Skeletal / physiology*
  • Muscular Dystrophies / physiopathology
  • NFATC Transcription Factors / physiology
  • Peroxisome Proliferator-Activated Receptors / physiology
  • Rats
  • Signal Transduction / physiology*

Substances

  • NFATC Transcription Factors
  • Peroxisome Proliferator-Activated Receptors
  • Calcineurin