Research on antibacterial and antifungal agents. IX--Synthesis and microbiological activity of new N-arylpyrroles

G C Porretta; M Biava; R Fioravanti; A Villa; N Simonetti

Research on antibacterial and antifungal agents. IX--Synthesis and microbiological activity of new N-arylpyrroles

Farmaco. 1991 Jul-Aug;46(7-8):987-95.

Authors

G C Porretta¹, M Biava, R Fioravanti, A Villa, N Simonetti

Affiliation

¹ Dipartimento di Studi di Chimica, Università Degli Studi di Roma La Sapienza, Italy.

PMID: 1793479

Abstract

The synthesis and antiblastomycete activity of new N-arylpyrrole derivatives are reported. Antimicrobial data in comparison with those obtained with pyrrolnitrin and miconazole showed that all tested compounds possess weak or poor activity. The obtained results are discussed on the basis of structure-activity relationships.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Candida / drug effects
Fungi / drug effects
Miconazole / pharmacology
Microbial Sensitivity Tests
Pyrroles / chemical synthesis*
Pyrroles / pharmacology
Pyrrolnitrin / pharmacology
Structure-Activity Relationship

Substances

Antifungal Agents
Pyrroles
Miconazole
Pyrrolnitrin