Historically, the office visit for a man complaining of sexual dysfunction focused on erectile dysfunction (ED). Over the past several years, epidemiologic studies and novel data have mandated that the clinician redirect this office visit. The office visit has now expanded into a variety of other areas, including premature ejaculation, libido, and hypogonadism as well as a cardiovascular assessment in light of the data suggesting that ED may be a sentinel sign of cardiovascular disease. This article provides the rationale for this global assessment paradigm.