Nramp1 phagocyte intracellular metal withdrawal defense

Mathieu F Cellier; Pascal Courville; Carole Campion

doi:10.1016/j.micinf.2007.09.006

Nramp1 phagocyte intracellular metal withdrawal defense

Microbes Infect. 2007 Nov-Dec;9(14-15):1662-70. doi: 10.1016/j.micinf.2007.09.006. Epub 2007 Sep 15.

Authors

Mathieu F Cellier¹, Pascal Courville, Carole Campion

Affiliation

¹ INRS-Institut Armand-Frappier, 531, Bd des prairies, Laval, Québec H7V 1B7, Canada. mathieu.cellier@iaf.inrs.ca

PMID: 18024118
DOI: 10.1016/j.micinf.2007.09.006

Abstract

Natural resistance-associated macrophage proteins (Nramp) are multispecific symporters facilitating proton-dependent import of divalent metals. Nramp1 restricts microbial access to essential micro-nutrients such as iron and manganese within professional phagosomes. Increased understanding of Nramp1 roles in human phagocytes will be useful for future therapeutic approaches against selected infectious and immune diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Cation Transport Proteins / chemistry
Cation Transport Proteins / genetics
Cation Transport Proteins / metabolism*
Cell Line
Eukaryotic Cells / immunology
Humans
Iron / metabolism*
Manganese / metabolism*
Mice
Molecular Sequence Data
Phagocytes / immunology
Phagocytes / metabolism*

Substances

Cation Transport Proteins
natural resistance-associated macrophage protein 1
Manganese
Iron