Abstract
Intraperitoneal injections of lysine acetylsalicylate (L-ASA, aspirin) in a dose of 10 mg during 5 consecutive days to BALB/c and B10.PL mice increased the concentration of endogenous hydrogen sulfide in their livers. The rise of hydrogen sulfur levels was shown also in brains of BALB/c females and B10.PL males, however in BALB/c male brains there is no statistically significant difference. The mechanism of aspirin action on H2S concentration is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
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Aspirin / administration & dosage
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Aspirin / analogs & derivatives*
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Brain / metabolism*
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Brain Chemistry
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Female
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Humans
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Hydrogen Sulfide / analysis
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Hydrogen Sulfide / metabolism*
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Liver / chemistry
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Liver / metabolism*
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Lysine / administration & dosage
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Lysine / analogs & derivatives*
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Male
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Mice
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Mice, Inbred BALB C
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Nitric Oxide / metabolism
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S-Adenosylmethionine / metabolism*
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Sex Factors
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Nitric Oxide
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S-Adenosylmethionine
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Lysine
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Aspirin
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acetylsalicylic acid lysinate
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Hydrogen Sulfide