28 men and 32 women were given Vingiano's Hemisphericity Questionnaire and the Coopersmith Self-esteem Inventory. People who reported the greatest numbers of right hemispheric indicators displayed the lowest self-esteem; the correlations were moderately strong (r greater than 50) for both men and women. These results support the hypothesis that the sense of self is primarily a linguistic, left-hemispheric phenomenon and that a developmental history of frequent intrusion from right-hemispheric processes can infuse the self-concept with negative affect.