Orbital invasion despite topical anti-metabolite therapy for conjunctival carcinoma

Graefes Arch Clin Exp Ophthalmol. 2008 Mar;246(3):459-61. doi: 10.1007/s00417-007-0742-y. Epub 2008 Jan 12.

Abstract

Background: Two cases of conjunctival carcinoma developed orbital invasion during treatment with topical medication.

Methods: This was a retrospective study from a tertiary ophthalmic oncology unit, performed after informed consent was obtained. The main outcome measurement was orbital invasion.

Results: Two patients treated with topical agents developed orbital invasion.

Conclusion: While topical agents are important in treatment of conjunctival neoplasia, recurrence or deep invasion require careful monitoring.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Antimetabolites, Antineoplastic / therapeutic use*
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / secondary*
  • Conjunctival Neoplasms / drug therapy
  • Conjunctival Neoplasms / pathology*
  • Fluorouracil / therapeutic use
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use
  • Magnetic Resonance Imaging
  • Male
  • Mitomycin / therapeutic use
  • Neoplasm Recurrence, Local / diagnosis*
  • Orbital Neoplasms / diagnosis
  • Orbital Neoplasms / secondary*
  • Recombinant Proteins
  • Retrospective Studies

Substances

  • Antimetabolites, Antineoplastic
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Mitomycin
  • Fluorouracil