Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis

J Infect Dis. 2008 Feb 15;197(4):618-21. doi: 10.1086/526500.

Abstract

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aspergillosis / genetics
  • Aspergillosis / immunology
  • Aspergillosis, Allergic Bronchopulmonary / genetics
  • Aspergillosis, Allergic Bronchopulmonary / immunology*
  • Aspergillus fumigatus / immunology*
  • Aspergillus fumigatus / pathogenicity
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Humans
  • Lung Diseases, Fungal / genetics
  • Lung Diseases, Fungal / immunology*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Toll-Like Receptor 2 / genetics
  • Toll-Like Receptor 4 / genetics*
  • Toll-Like Receptor 9 / genetics*

Substances

  • TLR2 protein, human
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Toll-Like Receptor 9