Abstract
In a recent issue of Molecular Cell, Yoon et al. provide evidence for the control of nucleocytoplasmic transport by protein kinase signaling pathways through phosphorylation of RanBP3, an accessory factor in the Ran GTPase system. This mechanism may coordinate nucleocytoplasmic transport with other mitogenic effects of these pathways.
MeSH terms
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Active Transport, Cell Nucleus / physiology*
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Humans
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Models, Biological
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Nuclear Proteins / metabolism
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Nucleocytoplasmic Transport Proteins / metabolism
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Signal Transduction / physiology*
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ran GTP-Binding Protein / metabolism
Substances
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Nuclear Proteins
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Nucleocytoplasmic Transport Proteins
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RAN protein, human
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RANBP3 protein, human
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ran GTP-Binding Protein