The effects of MK-801, an NMDA receptor antagonist, on the micturition reflex in the rat

Neurosci Lett. 1991 May 27;126(2):141-4. doi: 10.1016/0304-3940(91)90539-6.

Abstract

The effects of MK-801 (Dizocilpine) on the micturition reflex were studied in rats anesthetized with urethane (1.2 g/kg, s.c.). MK-801, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist (1-1000 micrograms/kg, i.v.) reduced, in a dose-dependent fashion the amplitude of rhythmic bladder contractions recorded isovolumetrically via a transurethral catheter. The largest doses (300-1000 micrograms/kg) completely abolished bladder activity. Bilateral section of the hypogastric nerves had no effect on MK-801 induced inhibition. MK-801 did not inhibit the bladder contractions induced by electrical stimulation of the pelvic nerve. These data suggest that MK-801 acts in the central nervous system to block glutaminergic excitatory transmission in the central micturition reflex pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dizocilpine Maleate / pharmacology*
  • Dose-Response Relationship, Drug
  • Female
  • Muscle Contraction / drug effects
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
  • Reflex / drug effects*
  • Urination / drug effects*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • Dizocilpine Maleate