Single nucleotide polymorphism typing of Bacillus anthracis from Sverdlovsk tissue

Richard T Okinaka; Melinda Henrie; Karen K Hill; Kristin S Lowery; Matthew Van Ert; Talima Pearson; James Schupp; Leo Kenefic; Jodi Beaudry; Steven A Hofstadler; Paul J Jackson; Paul Keim

doi:10.3201/eid1404.070984

Single nucleotide polymorphism typing of Bacillus anthracis from Sverdlovsk tissue

Emerg Infect Dis. 2008 Apr;14(4):653-6. doi: 10.3201/eid1404.070984.

Authors

Richard T Okinaka¹, Melinda Henrie, Karen K Hill, Kristin S Lowery, Matthew Van Ert, Talima Pearson, James Schupp, Leo Kenefic, Jodi Beaudry, Steven A Hofstadler, Paul J Jackson, Paul Keim

Affiliation

¹ Los Alamos National Laboratory, Los Alamos, New Mexico, USA.

Abstract

A small number of conserved canonical single nucleotide polymorphisms (canSNP) that define major phylogenetic branches for Bacillus anthracis were used to place a Sverdlovsk patient's B. anthracis genotype into 1 of 12 subgroups. Reconstruction of the pagA gene also showed a unique SNP that defines a new lineage for B. anthracis.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Anthrax / epidemiology*
Anthrax / microbiology
Antigens, Bacterial / genetics
Bacillus anthracis / classification*
Bacillus anthracis / genetics*
Bacterial Proteins / genetics
Bacterial Toxins / genetics
DNA, Bacterial / chemistry
Genotype
Humans
Inhalation Exposure
Phylogeny
Polymorphism, Single Nucleotide*
Russia / epidemiology

Substances

Antigens, Bacterial
Bacterial Proteins
Bacterial Toxins
DNA, Bacterial
anthrax toxin