Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Ann Neurol. 2008 Jul;64(1):88-92. doi: 10.1002/ana.21405.

Abstract

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / ethnology
  • Asian People / genetics*
  • DNA Mutational Analysis
  • Female
  • Founder Effect
  • Gene Frequency
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Male
  • Middle Aged
  • Mutation / genetics
  • Parkinson Disease / ethnology
  • Parkinson Disease / genetics*
  • Parkinson Disease / metabolism
  • Polymorphism, Genetic / genetics*
  • Protein Serine-Threonine Kinases / genetics*
  • Singapore / epidemiology
  • Taiwan / epidemiology

Substances

  • Genetic Markers
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein Serine-Threonine Kinases