Abstract
We studied the effect of prostaglandins on presynaptic NMDA receptors. Prostaglandin E2 inhibited NMDA-induced (45)Ca2+ uptake by synaptosomes in low concentrations (IC50 approximately 10 microM), but potentiated it in higher concentrations. Prostaglandin D2 increased (45)Ca2+ uptake by synaptosomes during stimulation of NMDA receptors. Our results indicate that prostaglandins D2 and E2 modulate function of presynaptic NMDA receptors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Calcium / metabolism
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Cerebral Cortex / cytology
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Cerebral Cortex / metabolism*
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Dinoprostone / metabolism*
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Presynaptic Terminals / metabolism*
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Prostaglandin D2 / metabolism*
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Rats
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Rats, Wistar
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Receptors, N-Methyl-D-Aspartate / metabolism*
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Synaptosomes / metabolism
Substances
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Receptors, N-Methyl-D-Aspartate
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Dinoprostone
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Prostaglandin D2
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Calcium