Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici

Ling Liu; Renrong Tian; Shuchun Liu; Xulin Chen; Liangdong Guo; Yongsheng Che

doi:10.1016/j.bmc.2008.04.052

Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici

Bioorg Med Chem. 2008 Jun 1;16(11):6021-6. doi: 10.1016/j.bmc.2008.04.052. Epub 2008 Apr 25.

Authors

Ling Liu¹, Renrong Tian, Shuchun Liu, Xulin Chen, Liangdong Guo, Yongsheng Che

Affiliation

¹ Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.

PMID: 18468908
DOI: 10.1016/j.bmc.2008.04.052

Abstract

Pestaloficiols A-E (1-5), five new cyclopropane derivatives, have been isolated from cultures of the plant endophyte Pestalotiopsis fici. The structures of these compounds were determined by NMR spectroscopy, and the absolute configuration of 1 was assigned using the modified Mosher method. Compounds 1, 2, and 4 displayed inhibitory effects on HIV-1 replication in C8166 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology
Ascomycota / chemistry*
Cyclopropanes / chemistry*
Cyclopropanes / pharmacology
HIV-1 / drug effects
HIV-1 / growth & development
Heterocyclic Compounds, 3-Ring / chemistry*
Heterocyclic Compounds, 3-Ring / pharmacology*
Plants / microbiology*
Protein Isoforms / chemistry
Protein Isoforms / pharmacology
Sesquiterpenes / chemistry*
Sesquiterpenes / pharmacology*
Virus Replication / drug effects

Substances

Anti-HIV Agents
Cyclopropanes
Heterocyclic Compounds, 3-Ring
Protein Isoforms
Sesquiterpenes
pestalotheol C
pestalotiopsin A
cyclopropane