IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines

George M Buckley; Richard Fosbeary; Joanne L Fraser; Lewis Gowers; Alicia P Higueruelo; Lynwen A James; Kerry Jenkins; Stephen R Mack; Trevor Morgan; David M Parry; William R Pitt; Oliver Rausch; Marianna D Richard; Verity Sabin

doi:10.1016/j.bmcl.2008.04.042

IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60. doi: 10.1016/j.bmcl.2008.04.042. Epub 2008 Apr 24.

Authors

George M Buckley¹, Richard Fosbeary, Joanne L Fraser, Lewis Gowers, Alicia P Higueruelo, Lynwen A James, Kerry Jenkins, Stephen R Mack, Trevor Morgan, David M Parry, William R Pitt, Oliver Rausch, Marianna D Richard, Verity Sabin

Affiliation

¹ UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.

PMID: 18501603
DOI: 10.1016/j.bmcl.2008.04.042

Abstract

Following the identification of a potent IRAK inhibitor through routine project cross screening, a novel class of IRAK-4 inhibitor was established. The SAR of imidazo[1,2-a]pyridino-pyridines and benzimidazolo-pyridines was explored.

MeSH terms

Drug Evaluation, Preclinical
Interleukin-1 Receptor-Associated Kinases / antagonists & inhibitors*
Molecular Structure
Protein Kinase Inhibitors / chemical synthesis
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*
Pyridines / chemical synthesis
Pyridines / chemistry
Pyridines / pharmacology*
Stereoisomerism
Structure-Activity Relationship

Substances

Protein Kinase Inhibitors
Pyridines
Interleukin-1 Receptor-Associated Kinases
imidazo(1,2-a)pyridine