SUMO amplifies TGF-beta signalling

Nat Cell Biol. 2008 Jun;10(6):635-7. doi: 10.1038/ncb0608-635.

Abstract

Transforming growth factor-beta (TGF-beta) stimulates phosphorylation of TGF-beta type I receptor. This receptor is now shown to be sumoylated, leading to enhanced activation and modulation of the downstream Smad signalling pathway.

Publication types

  • News

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Humans
  • Models, Biological
  • Mutation
  • Neoplasm Metastasis
  • Neoplasms / metabolism
  • Phosphorylation
  • SUMO-1 Protein / metabolism*
  • Signal Transduction
  • Transforming Growth Factor beta / metabolism*

Substances

  • SUMO-1 Protein
  • SUMO1 protein, human
  • Transforming Growth Factor beta