Abstract
Transforming growth factor-beta (TGF-beta) stimulates phosphorylation of TGF-beta type I receptor. This receptor is now shown to be sumoylated, leading to enhanced activation and modulation of the downstream Smad signalling pathway.
MeSH terms
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Animals
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Gene Expression Regulation*
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Humans
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Models, Biological
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Mutation
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Neoplasm Metastasis
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Neoplasms / metabolism
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Phosphorylation
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SUMO-1 Protein / metabolism*
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Signal Transduction
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Transforming Growth Factor beta / metabolism*
Substances
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SUMO-1 Protein
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SUMO1 protein, human
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Transforming Growth Factor beta