Abstract
An efficient arylation in water of tyrosine and phenylalanine side chains from unprotected iodopeptides is accomplished by using Suzuki-Miyaura cross-coupling processes. The method is compatible with the hydrophilic and thermolabile nature of biologically active peptides. Also of interest, the arylated tyrosine peptides can be accessed in one-pot mode starting from native peptides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enkephalin, Leucine / chemistry
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Iodoproteins / chemistry*
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Onium Compounds / chemistry
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Peptides / chemical synthesis*
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Peptides / chemistry
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Phenylalanine / chemistry*
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Pyridines / chemistry
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Tyrosine / chemistry*
Substances
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Iodoproteins
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Onium Compounds
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Peptides
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Pyridines
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bis(pyridine)iodonium(I) tetrafluoroborate
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Tyrosine
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Phenylalanine
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Enkephalin, Leucine